Controlling delivery of Carbamazepine drug using multi walled carbon nanotubes
Todays, nanomaterial-based drug delivery systems can help to control the release of drugs. In this study, multiwalled carbon nanotubes (MWCNTs) were used as reliable carriers to enhance the delivery of carbamazepine (CBZ). The adsorption of the CBZ drugs on the MWCNTs was determined using three adsorption models, such as Langmuir, Freundlich, and Temkin. High values of isothermal constant (b) and separation factor (RL) confirm strong and reliable adsorption of the CBZ drug with concentration of 60 mg L-1 at 303 Kelvin in acidic medium. Another important point is that the adsorption value decreases with increasing pH. The negative value of enthalpy (ΔH) based on Vant-Hoff equation shows that the adsorption of the CBZ drugs on the MWCNTs exhibits fast pseudo-first order kinetics and exothermic process in 90 minutes. Moreover, the negative value of Gibbs free energy (ΔG) shows that the adsorption of the CBZ drug on the MWCNTs is a spontaneous process. Therefore, all the above parameters indicate that the MWCNTs can be considered as a reliable carrier for the adsorption, transfer, and controlled release of the CBZ drugs into the target cells with little side effects.