Issues
Pharmacovigilance, drug interactions, pharmacogenetics and therapeutic drug monitoring of anticancer agents: a valuable support for clinical practice
Clinical Pharmacology is an integral part of Oncology, especially in the modern era of precision medicine. The innovations introduced in drug development (conditional accelerated tumor-agnostic approvals through adaptive trials) and clinical practice (liquid biopsy, tumor molecular board) underline the pressing need for clinical pharmacologists, who play a catalyst and translational role in a synchronized multidisciplinary team. This review describes the latest advancements and challenges in actually implementing the precision medicine approach in Oncology: pharmacovigilance, drug interactions, pharmacogenetics and therapeutic drug monitoring are often overlooked valuable tools for the understanding, detection, assessment, and prevention of adverse drug reactions, thus supporting safe prescribing in Oncology.
Impact statement
In the era of artificial intelligence and real world evidence, we strengthen the importance of clinical pharmacology as a patient-oriented discipline in Oncology.
Pharmacovigilance, Pharmacogenetics, Terapeutic Drug Monitoring are valuable tools to proactively implement precision medicine, namely prediction, prevention, detection, assessment of adverse drug reactions and clinically-important drug interactions.
Safe Prescribing in Oncology is a challenging but feasible mission for Clinical Pharmacolgists.
