Rethinking post-mortem tryptase: a critical analysis of its role in diagnosing anaphylactic deaths

SUMMARY
Post-mortem tryptase is used to support the diagnosis of anaphylaxis. However, despite its common use, the interpretation of elevated tryptase levels is still debated among experts. This review critically examines the use of post-mortem tryptase levels to identify fatalities resulting from anaphylaxis within forensic pathology. By synthesizing data from multiple studies, we aim to evaluate the reliability and consistency of post-mortem tryptase as a marker for anaphylactic deaths. Our methodical approach sheds light on the complexities and potential confounding factors in interpreting elevated tryptase levels. The findings suggest that the current understanding of post-mortem tryptase may require cautious interpretation and highlight the need for a more nuanced approach in forensic examinations. This review calls for a reassessment of existing methodologies and encourages further research to enhance our understanding in this crucial area of forensic science.

Impact statement
This study suggests that the current understanding of post-mortem tryptase may require cautious interpretation and encourages further research to better understand its role.