The novel fentanyl-analog “Acrylofentanyl” impairs motor, sensorimotor and cardiovascular functions in mice.
Synthetic opioids are a large class of new psychoactive substances (NPS) mostly consisting of analogs of fentanyl (Fen) that have caused numerous overdose and fatalities worldwide. In 2016 the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) has reported a total of 130 deaths caused by a new psychoactive substance called “Acrylofentanyl” in United States and Europe. Acrylofentanyl (AcrylF) was spreading online as a research chemical and was mostly sold in a powder or nasal
spray forms. It is a potent NPS that is being used and abused causing more than 21 intoxications and 47 deaths in Europe within a relatively short time period. The aim of the present study was to compare the acute effects evoked by AcrylF, Fen and morphine
(mor) on motor, sensorimotor and cardio-respiratory changes in mice. To better understand the pharmacological action of AcrylF, we used naloxone as opioid receptor antagonist.