Ultrasonic communication deficits in p50 KO mice and effect of maternal enrichment

Mice emit ultrasonic vocalizations (USVs) under different social conditions: pups maternal separation, juveniles play and adults mating and social investigation. The USVs measurement has become an important instrument for behavioral phenotyping in neurodevelopmental disorders (NDDs). Many studies have shown the fundamental role of maternal enrichment with long-term positive effects on brain and behavior in mouse models of NDDs. In this study, we wanted to investigate if mice lacking the NF-ĸB p50 subunit (p50 knock-out, KO) that are a mouse model of NDDs, had alterations in ultrasonic communication and if these calling patterns were influenced by maternal behavior.

Table of Content: Vol. 2 (No.1) 2020 April